Theracne 365 Active Serum 30ml
Clinical acne serum - measurable results in 7 days.
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Benefits
275% improvement in skin texture and 192% improvement in pore appearance in 7 days - Zinc, BHA (Salicylic Acid), and a dual AHA complex (Glycolic and Lactic Acid) work simultaneously on sebum, dead skin, and pore congestion for multi-front acne care.
16.9% reduction in sebum production and 34.5% reduction in pore area - clinically verified results after seven days of use, based on Amorepacific skin research clinical testing on 29 acne-prone subjects.
Addresses post-blemish marks alongside active breakouts - 4.7% improvement in pigmentation and 100% of participants reported more radiant skin after two weeks, making this a treatment for the full acne cycle - active, healing, and post-mark stages.
Non-sticky, fast-absorbing texture - dermatologist-tested, allergy-tested, and non-comedogenic - a clinical serum that wears comfortably under moisturizer and SPF without heaviness.
Hero Ingredients
Zinc Chloride + Zinc PCA
What it does: Two complementary zinc actives addressing sebum control from different angles - Zinc Chloride provides direct soothing and oil-regulating action, while Zinc PCA is a sebum-absorbing and anti-bacterial form of zinc that reduces excess oil production with consistent use. Together they drive the 16.9% reduction in sebum production shown in clinical testing after seven days.
Why we chose it: Dual zinc delivery is a more sophisticated approach than the single Zinc Chloride used in the Theracne Toner - this is the active treatment level of the Theracne system, and the ingredient formulation reflects that.
BHA + Dual AHA
What it does: A triple-acid exfoliation system - BHA (Salicylic Acid) penetrates oil-filled pores to dissolve congestion from inside, while Glycolic Acid (the smallest AHA molecule) resurfaces dead skin cells at the surface and Lactic Acid smooths texture with a slightly gentler action. Together they reduce keratin buildup by 7.6%, improve whitehead and blackhead appearance by 16.8%, and deliver the 275% skin texture improvement in clinical testing.
Why we chose it: Three complementary exfoliants at the serum level is what separates this from a basic BHA toner - each acid works at a different depth and mechanism, delivering comprehensive exfoliation that single-acid products can't match.
Madecassoside + Asiaticoside + Asiatic Acid + Madecassic Acid
What it does: The full Centella Asiatica active complex - not just an extract but the four purified bioactive compounds that make Centella clinically effective. They work together to calm inflammation, support barrier repair, and reduce the redness associated with active acne and post-blemish healing, counterbalancing the drying and exfoliating action of the zinc and acid system.
Why we chose it: Including the full Centella active complex in an acne serum is the formulation decision that makes aggressive pore treatment comfortable for daily use - it soothes while the actives work rather than requiring a separate calming step.
Studio Pick
The Aestura Theracne 365 Active Serum is the clinical core of the Theracne system - and the product we'd recommend to acne-prone customers who've tried gentler options and need a more targeted treatment. The clinical data after just seven days is genuinely impressive: 275% skin texture improvement and 192% pore appearance improvement are the kind of numbers that reflect serious formulation rigour, not marketing claims. Developed by Amorepacific's research specialists, tested on acne-prone skin specifically, and built to work as a system with the Theracne Toner and Cleanser - this is clinical acne care that earns its description.
Curation Score: 9.0 / 10
Ingredient Quality 9/10 - Brand Reputation 9/10 - Community Consensus 8/10 - Value for Money 9/10 - Versatility 8/10
Skin Compatibility
Formulated specifically for oily, acne-prone, and combination skin.
Non-comedogenic, dermatologist-tested, and allergy-tested. Contains Alcohol Denat., BHA (Salicylic Acid), Glycolic Acid, and Lactic Acid - always follow with broad-spectrum SPF in the morning. Contains Zanthoxylum Piperitum (Pepper) Oil and Menthoxypropanediol which create a mild cooling sensation - not suitable for skin reactive to menthol or pepper-derived ingredients. Introduce gradually - start with evening use only for the first two weeks before building to morning and evening. Not recommended for use on broken or actively wounded skin.
How to Use
- After cleansing and toning, apply an appropriate amount evenly across the face
- Allow the serum to absorb fully before applying moisturizer
- Use morning and evening for optimal results
- Always apply broad-spectrum SPF during the day - essential when using BHA and AHA exfoliating actives
For new users: start with evening use only for the first two weeks and build to twice daily as skin adjusts
Pairs well with: Aestura Theracne 365 Hydro Active Toner used before for a complete clinical Theracne acne routine
Full Ingredients
Water/Aqua/Eau, Butylene Glycol, Glycerin*, Alcohol Denat.†, Niacinamide*, 1,2-Hexanediol, Silica*, Diethoxyethyl Succinate, Helianthus Annuus (Sunflower) Seed Oil*, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Ammonium Acryloyldimethyltaurate/VP Copolymer, Tromethamine, Salicylic Acid* (BHA), Xanthan Gum, Dipotassium Glycyrrhizate*, Glyceryl Caprylate, Lactic Acid*, Disodium EDTA, Menthoxypropanediol*, Ethylhexylglycerin, Sorbitan Isostearate, Lupinus Albus (White Lupin) Seed Extract*, Citric Acid, Zinc Chloride*, Zinc PCA*, Glycolic Acid*, Asiaticoside*, Zanthoxylum Piperitum (Pepper) Oil†, Madecassic Acid*, Asiatic Acid*, Tocopherol*
*Active/notable ingredients: Glycerin (humectant), Niacinamide (brightening, blemish reduction, barrier support), Silica (oil absorption, texture mattifying), Sunflower Seed Oil (emollient, skin-compatible oil), Salicylic Acid/BHA (pore clearing, exfoliation), Dipotassium Glycyrrhizate (licorice-derived, soothing, smoothing), Lactic Acid/AHA (surface exfoliation, texture refinement), Menthoxypropanediol (cooling agent), Lupinus Albus/White Lupin Seed Extract (pore refinement, anti-sebum), Zinc Chloride + Zinc PCA (dual zinc - sebum control, soothing, anti-bacterial), Glycolic Acid/AHA (surface exfoliation, skin renewal), Asiaticoside + Madecassic Acid + Asiatic Acid (Centella actives - calming, barrier repair, anti-inflammatory), Tocopherol (antioxidant, Vitamin E)
†Contains Alcohol Denat. and Zanthoxylum Piperitum (Pepper) Oil - produces a mild cooling/warming sensation. Not suitable for those reactive to menthol or pepper-derived ingredients. Patch test recommended.
Free from: animal-derived ingredients, mineral oil, polyacrylamides, tar colorants, silicone oil, PEG
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Frequently Asked
Is this suitable for sensitive skin as well as acne-prone skin?
This is a clinical acne treatment formulated primarily for oily and acne-prone skin - it contains Alcohol Denat., BHA, dual AHA, and Pepper Oil which may be too active for sensitive skin without acne concerns. For sensitive skin that also struggles with breakouts, introduce gradually with evening use only and monitor skin response. If persistent redness, dryness, or irritation occurs, reduce to every other evening. For sensitive skin seeking gentler acne care, the COSRX Advanced Snail 96 or SKIN1004 Centella Ampoule in our range are better-suited starting points.
Where does this sit in the Theracne 365 routine?
The Theracne routine runs: Theracne Cleansing Foam - Theracne Hydro Active Toner - Theracne Active Serum - moisturizer. The serum goes after toner as your treatment step, before moisturizer and SPF. Each product in the Theracne line addresses a different part of the acne cycle - the cleanser clears the pore, the toner controls sebum and exfoliates, the serum provides intensive treatment-level active care. The clinical results for each product are based on the full routine sequence.
Why does this use three different acids and what does each one do?
Each acid works at a different depth and mechanism. BHA (Salicylic Acid) is oil-soluble - it penetrates into pores to dissolve congestion from inside. Glycolic Acid is the smallest AHA molecule and resurfaces dead skin cells at the surface most efficiently. Lactic Acid exfoliates at the surface with a slightly gentler action, also improving moisture retention. Together they cover inside the pore, the skin surface, and the texture layer - delivering the 275% skin texture improvement and 192% pore appearance improvement in clinical testing that a single-acid approach couldn't achieve.
I notice a mild cooling sensation when I apply this - is that normal?
Yes - the cooling sensation comes from Menthoxypropanediol and Zanthoxylum Piperitum (Pepper) Oil in the formula. It's a deliberate formulation choice that gives the serum a fresh, immediate feel on application and helps signal the active ingredients working on the skin. If the sensation feels intense or causes visible redness, rinse the area and reduce application frequency. Those who react to menthol or cooling agents should patch test before first full use.
How long will 30ml last?
Used twice daily with an appropriate amount per application, 30ml typically lasts 4-6 weeks. A thin, even layer across the face is sufficient - the serum is concentrated and doesn't need to be applied heavily to deliver the clinical results. Always follow with SPF in the morning. Store at room temperature away from direct sunlight - the BHA and AHA actives benefit from stable, cool storage. Use within 12 months of opening.